Article
Mitochondrial genetic background plays a role in increasing risk to asthma.
Molecular biology reports - 1 Apr 2012
Zifa Emily, Daniil Zoe, Skoumi Eleutheria, Stavrou Maria, Papadimitriou Kostantinos, Terzenidou Marini, Kostikas Konstantinos, Bagiatis Vasileios, Gourgoulianis Konstantinos I, Mamuris Zissis
Abstract excerpt
A number of studies suggest that mitochondrial dysfunction plays a role in the pathogenesis of asthma. To shed light for the first time on the role of the mitochondrial genome in the etiology of asthma we analyzed the mitochondrial tRNA genes and part of their flanking regions in patients with asthma compared with a set of healthy controls. We found a total of 10 mutations in 56 out of 76 asthmatic patients. Four...
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