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Article

An epigenome-wide association study of total serum immunoglobulin E concentration.

Nature - 30 Apr 2015

Liang Liming, Willis-Owen Saffron A G, Laprise Catherine, Wong Kenny C C, Davies Gwyneth A, Hudson Thomas J, Binia Aristea, Hopkin Julian M, Yang Ivana V, Grundberg Elin, Busche Stephan, Hudson Marie, Rönnblom Lars, Pastinen Tomi M, Schwartz David A, Lathrop G Mark, Moffatt Miriam F, Cookson William O C M

Abstract excerpt

Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies directed against IgE can alleviate hay fever and allergic asthma. Genetic association studies have not yet identified novel therapeutic targets or pathways underlying IgE regulation. We therefore surveyed epigenetic associations between serum IgE concentrations and methylation at loci concentrated in CpG islands genome wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25707804
DOI: 10.1038/nature14125
PMCID: PMC4416961

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