Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.

Journal of neurochemistry - 1 Nov 2007

Levi Ofir, Dolev Iftach, Belinson Haim, Michaelson Daniel M

Abstract excerpt

The allele E4 of apolipoprotein E4 (apoE4), which is the most prevalent genetic risk factor of Alzheimer's disease (AD), inhibits synaptogenesis and neurogenesis and stimulates apoptosis in brains of apoE4 transgenic mice that have been exposed to an enriched environment. In the present study, we investigated the hypothesis that the brain activity-dependent impairments in neuronal plasticity, induced by apoE4,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Apolipoprotein E3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Dentate Gyrus

Share to Neuronal Plasticity

Share to Neurons

Share to Plaque, Amyloid

Share to Polymers

Source

Identifiers

PMID: 17666042
DOI: 10.1111/j.1471-4159.2007.04810.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.PMID 17666042Read ↗

Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic miceSemantic proximity Read ↗

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.Semantic proximity Read ↗

Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw.Semantic proximity Read ↗

Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's diseaseSemantic proximity Read ↗

The short-term improvements of enriched environment in behaviors and pathological changes of APP/PS1 mice via regulating cytokines.Semantic proximity Read ↗

Moderate environmental enrichment mitigates tauopathy in a neurofibrillary tangle mouse model.Semantic proximity Read ↗

Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's DiseaseSemantic proximity Read ↗

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse ModelSemantic proximity Read ↗

Environmental Enrichment Prevents Transcriptional Disturbances Induced by Alpha-Synuclein OverexpressionSemantic proximity Read ↗

Enriched environment requires remodeling of hippocampal perineuronal nets to trigger memory improvement in Alzheimer’s mouse modelSemantic proximity Read ↗

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Semantic proximity Read ↗

Early Amyloid-β Deposits and Astrogliosis Are Modulated by Housing Conditions in 5xFAD MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.