Article
Diverse requirements for Notch signalling in mammals.
The International journal of developmental biology - 1 Jan 2002
Sparrow Duncan B, Clements Melanie, Withington Sarah L, Scott Annabelle N, Novotny Jiri, Sillence David, Kusumi Kenro, Beddington Rosa S P, Dunwoodie Sally L
Abstract excerpt
The Notch signalling pathway has a central role in a wide variety of developmental processes and it is not therefore surprising that mutations in components of this pathway can cause dramatic human genetic disorders. One developmental process in which the Notch pathway is involved at multiple levels is somitogenesis, the mechanism by which the embryo is divided into segments that ultimately form structures such...
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