Article
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands.
The Journal of cell biology - 12 Sept 2005
Ladi Ena, Nichols James T, Ge Weihong, Miyamoto Alison, Yao Christine, Yang Liang-Tung, Boulter Jim, Sun Yi E, Kintner Chris, Weinmaster Gerry
Abstract excerpt
Mutations in the DSL (Delta, Serrate, Lag2) Notch (N) ligand Delta-like (Dll) 3 cause skeletal abnormalities in spondylocostal dysostosis, which is consistent with a critical role for N signaling during somitogenesis. Understanding how Dll3 functions is complicated by reports that DSL ligands both activate and inhibit N signaling. In contrast to other DSL ligands, we show that Dll3 does not activate N signaling...
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