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Article

Context-dependent mutation rates may cause spurious signatures of a fixation bias favoring higher GC-content in humans.

Molecular biology and evolution - 1 Oct 2007

Hernandez Ryan D, Williamson Scott H, Zhu Lan, Bustamante Carlos D

Abstract excerpt

Understanding the proximate and ultimate causes underlying the evolution of nucleotide composition in mammalian genomes is of fundamental interest to the study of molecular evolution. Comparative genomics studies have revealed that many more substitutions occur from G and C nucleotides to A and T nucleotides than the reverse, suggesting that mammalian genomes are not at equilibrium for base composition. Analysis...

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PMID: 17656634
DOI: 10.1093/molbev/msm149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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