Article
MYC amplification and TERT expression in breast tumor progression.
Cancer genetics and cytogenetics - 15 Jul 2007
Bodvarsdóttir Sigríthur K, Steinarsdóttir Margrét, Hilmarsdóttir Hólmfríthur, Jónasson Jón G, Eyfjörd Jorunn E
Abstract excerpt
The complex roles of genomic instability, MYC oncogene amplification, activation of telomerase, and p53 function still remain to be fully described in breast tumors. MYC stimulates the telomerase catalytic subunit, TERT, which interacts with p53. Oncogene MYC amplification analysis was performed on 27 paraffin-embedded breast tumor samples by fluorescence in situ hybridization, selected on the basis of...
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