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Telomerase Activity in Human Breast Tumors

17 Jan 1996

Abstract excerpt

BACKGROUND: The activity of the ribonucleoprotein enzyme telomerase is not detected in normal somatic cells; thus, with each cell division, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode. The current model gaining support is that telomerase activity in germline and immortal cells maintains telomere length and thus compensates for the "end-replication problem." PURPOSE: Our...

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PMID: 8537972
DOI: 10.1093/jnci/88.2.116

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