Telomerase activity in relation to p53 status and clinico-pathological parameters in breast cancer.

doi:10.1002/(sici)1097-0215(19980821)79:4<343::aid-ijc6>3.0.co;2-v

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Article

Telomerase activity in relation to p53 status and clinico-pathological parameters in breast cancer.

International journal of cancer - 21 Aug 1998

Roos G, Nilsson P, Cajander S, Nielsen N H, Arnerlöv C, Landberg G

Abstract excerpt

Cell cycle deregulation can occur at different levels in cancer. In human breast cancer it includes overexpression of cyclins D1 and E, down-regulation of cyclin-dependent kinase inhibitors and inactivation of the retinoblastoma and p53 tumor suppressor proteins. Telomerase activity is strongly a...

Topics

Breast Neoplasms
Genes, p53
Humans
Lymphatic Metastasis
Mutation
Polymorphism, Single-Stranded Conformational
Prognosis
Telomerase
Time Factors
Tumor Suppressor Protein p53

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