Article
Telomerase activity in relation to p53 status and clinico-pathological parameters in breast cancer.
International journal of cancer - 21 Aug 1998
Roos G, Nilsson P, Cajander S, Nielsen N H, Arnerlöv C, Landberg G
Abstract excerpt
Cell cycle deregulation can occur at different levels in cancer. In human breast cancer it includes overexpression of cyclins D1 and E, down-regulation of cyclin-dependent kinase inhibitors and inactivation of the retinoblastoma and p53 tumor suppressor proteins. Telomerase activity is strongly associated with an immortal phenotype and expression of telomerase is linked to the cell cycle. We have recently...
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