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Article

Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer.

International journal of molecular sciences - 5 May 2022

Dratwa Marta, Wysoczanska Barbara, Brankiewicz Wioletta, Stachowicz-Suhs Martyna, Wietrzyk Joanna, Matkowski Rafał, Ekiert Marcin, Szelachowska Jolanta, Maciejczyk Adam, Szajewski Mariusz, Baginski Maciej, Bogunia-Kubik Katarzyna

Abstract excerpt

The molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the expression of the TERT, MYC, TP53 and SP1 genes in BC patients and in BC organoids (3D cell cultures obtained from breast cancer tissues). We observed the same...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35563554
DOI: 10.3390/ijms23095164
PMCID: PMC9102200

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