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Article

Analysis of MMP2-1306C/T and TIMP2G-418C polymorphisms with relapsing remitting multiple sclerosis.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Aug 2016

Aksoy Dürdane, Ateş Ömer, Kurt Semiha, Çevik Betül, Sümbül Orhan

Abstract excerpt

AIMS: Multiple sclerosis (MS) is an autoimmune, inflammatory disease characterized by loss of myelin forming oligodendrocytes and changes in the blood-brain barrier. Matrix metalloproteinase (MMP) -2 and -9 are known to cause disruption of the blood-brain barrier, remodeling of the basal lamina, regeneration of axons, and remyelination in MS. The imbalance between MMPs and tissue inhibitor metalloproteinases...

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Source

Identifiers

PMID: 27174941
DOI: 10.1136/jim-2016-000111

Genes

MMP2
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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