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Article

The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb-E2F1.

The Biochemical journal - 15 Nov 2007

Liu Yongqing, Costantino Mary E, Montoya-Durango Diego, Higashi Yujiro, Darling Douglas S, Dean Douglas C

Abstract excerpt

ZFHX1A is expressed in proliferating cells in the developing embryo, and in the present study we provide evidence that its expression is confined to proliferating cells through dependence on the Rb (retinoblastoma protein) family/E2F cell cycle pathway. Mutation of the Rb or E2F1 genes lead to induction of ZFHX1A mRNA, implying that the Rb-E2F1 repressor complex is important for repression of ZFHX1A. This...

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Identifiers

PMID: 17655524
DOI: 10.1042/BJ20070344
PMCID: PMC2049079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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