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Article

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.

Somatic cell and molecular genetics - 1 Jul 1998

Huang C C, Faber P W, Persichetti F, Mittal V, Vonsattel J P, MacDonald M E, Gusella J F

Abstract excerpt

Huntington's disease (HD) is caused by an expanded CAG trinucleotide repeat encoding a tract of consecutive glutamines near the amino terminus of huntingtin, a large protein of unknown function. It has been proposed that the expanded polyglutamine stretch confers a new property on huntingtin and thereby causes cell and region-specific neurodegeneration. Genotype-phenotype correlations predict that this novel...

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Identifiers

PMID: 10410676
DOI: 10.1023/b:scam.0000007124.19463.e5

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TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.PMID 10410676Read ↗

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