Article
Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis.
Human molecular genetics - 1 Nov 2007
Alizadeh Behrooz Z, Valdigem Gustavo, Coenen Marieke J H, Zhernakova Alexandra, Franke Barbara, Monsuur Alienke, van Riel Piet L C M, Barrera Pilar, Radstake Timothy R D J, Roep Bart O, Wijmenga Cisca, Koeleman Bobby P C
Abstract excerpt
FcgRIIa and FcgRIIIa are potent modulators of the immune system which bind (auto)antibodies and activate immune cells. The FcgRIIa*A519G and FcgRIIIa*A559C functional variants have been associated with several immune-related diseases. We studied FcgRIIa*A519G and FcgRIIIa*A559C SNPs in type 1 diabetes (T1D), celiac disease (CD) and rheumatoid arthritis (RA) patients and controls and included a meta-analysis of...
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