Article
Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations.
Inflammatory bowel diseases - 1 Dec 2010
Weersma Rinse K, Crusius J Bart A, Roberts Rebecca L, Koeleman Bobby P C, Palomino-Morales Rogelio, Wolfkamp Simone, Hollis-Moffatt Jade E, Festen Eleonora A M, Meisneris Sander, Heijmans Roel, Noble Colin L, Gearry Richard B, Barclay Murrary L, Gómez-Garcia María, Lopez-Nevot Miguel A, Nieto Antonio, Rodrigo Luis, Radstake Timothy R D J, van Bodegraven Adriaan A, Wijmenga Cisca, Merriman Tony R, Stokkers Pieter C F, Peña A Salvador, Martín Javier, Alizadeh Behrooz Z
Abstract excerpt
BACKGROUND: The Fc receptors II and III (FcgR2a, and FcgR3a) play a crucial role in the regulation of the immune response. The FcgR2a*519GG and FcgR3a*559CC genotypes have been associated with several autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, nephritis, and possibly to type I diabetes, and celiac disease. In a large multicenter, two-stage study of 6570 people, we tested...
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