Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells.

Pharmacological research - 1 Sept 2007

Yang Li-Hung, Chen Tzer-Ming, Yu Sung-Tsai, Chen Yen-Hui

Abstract excerpt

Olanzapine is a second-generation atypical antipsychotic drug (AAPD). Major side effects of olanzapine are weight gain and development of diabetes mellitus, which are risk factors of cardiovascular diseases. The possible causes of metabolic adverse effects are known as poor satiety and increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adipocytes
Share to Adipogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adiponectin

Share to Benzodiazepines

Share to Fatty Acid Synthases

Share to Olanzapine

Share to Sterol Regulatory Element Binding Protein 1

Source

Identifiers

PMID: 17651982
DOI: 10.1016/j.phrs.2007.05.007

Genes

EBP
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17651982-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells.PMID 17651982Read ↗

Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatinSemantic proximity Read ↗

Atypical antipsychotic (AAP)-induced metabolic toxicity : study of mechanisms, biomarkers and reversal strategiesSemantic proximity Read ↗

PCSK9 dysregulates cholesterol homeostasis and triglyceride metabolism in olanzapine-induced hepatic steatosis via both receptor -dependent and -independent pathwaysSemantic proximity Read ↗

Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats.Semantic proximity Read ↗

Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?Semantic proximity Read ↗

The Association of Olanzapine-Induced Weight Gain with Peroxisome Proliferator–Activated Receptor-γ2 Pro12Ala Polymorphism in Patients with SchizophreniaSemantic proximity Read ↗

Genetic Correlates of Olanzapine-Induced Weight Gain in Schizophrenia Subjects from North India: Role of Metabolic Pathway GenesSemantic proximity Read ↗

FADS1 modulates metabolic syndrome in schizophrenia patients receiving olanzapine monotherapy.Semantic proximity Read ↗

Weight Gain and Metabolic Changes During Treatment with Antipsychotics and Antidepressants.Semantic proximity Read ↗

Clozapine modifies the differentiation program of human adipocytes inducing browning.Semantic proximity Read ↗

Association between SCAP and SREBF1 gene polymorphisms and metabolic syndrome in schizophrenia patients treated with atypical antipsychotics.Semantic proximity Read ↗

Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.