Article
Clozapine modifies the differentiation program of human adipocytes inducing browning.
Translational psychiatry - 29 Nov 2016
Kristóf E, Doan-Xuan Q-M, Sárvári A K, Klusóczki Á, Fischer-Posovszky P, Wabitsch M, Bacso Z, Bai P, Balajthy Z, Fésüs L
Abstract excerpt
Administration of second-generation antipsychotic drugs (SGAs) often leads to weight gain and consequent cardio-metabolic side effects. We observed that clozapine but not six other antipsychotic drugs reprogrammed the gene expression pattern of differentiating human adipocytes ex vivo, leading to an elevated expression of the browning marker gene UCP1, more and smaller lipid droplets and more mitochondrial DNA...
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