Article

PCSK9 dysregulates cholesterol homeostasis and triglyceride metabolism in olanzapine-induced hepatic steatosis via both receptor -dependent and -independent pathways

2022-08-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Long-term olanzapine treatment reportedly induces nonalcoholic fatty liver disease (NAFLD); however, the underlying mechanism remains unclear. Proprotein convertase subtilisin kexin type 9 (PCSK9) degrades low-density lipoprotein receptor (LDLR) and is involved in NAFLD pathogenesis via unknown mechanisms. Here, we investigated the role and mechanism of PCSK9 in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9d1b775-9dbe-5585-91a7-7ef153a98f85
DOI: 10.21203/rs.3.rs-1890507/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PCSK9 dysregulates cholesterol homeostasis and triglyceride metabolism in olanzapine-induced hepatic steatosis via both receptor -dependent and -independent pathwaysDOI 10.21203/rs.3.rs-1890507/v1Read

PCSK7: a Novel Regulator of Apolipoprotein B and a Potential Target Against Non-Alcoholic Fatty Liver DiseaseSemantic proximity Read

Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells.Semantic proximity Read

Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis.Semantic proximity Read

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic StrategiesSemantic proximity Read

The next generation of novel low-density lipoprotein cholesterol-lowering agents: proprotein convertase subtilisin/kexin 9 inhibitors.Semantic proximity Read

Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects gene expression pathways beyond cholesterol metabolism in liver cells.Semantic proximity Read

PCSK9 pathway-noncoding RNAs crosstalk: Emerging opportunities for novel therapeutic approaches in inflammatory atherosclerosisSemantic proximity Read

Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatinSemantic proximity Read

Aaptamine Counteracts Statin-Induced PCSK9 Elevation to Improve LDL Receptor Expression and Cholesterol UptakeSemantic proximity Read

Targeting PCSK9 for the treatment of hypercholesterolemia.Semantic proximity Read

[Progress on the molecular mechanisms of PCSK9-mediated degradation of low density lipoprotein receptor].Semantic proximity Read

Suppression of Idol expression is an additional mechanism underlying statin-induced up-regulation of hepatic LDL receptor expressionSemantic proximity Read