Article
Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.
The Journal of clinical psychiatry - 1 Sept 2008
Ujike Hiroshi, Nomura Akira, Morita Yukitaka, Morio Akiko, Okahisa Yuko, Kotaka Tatsuya, Kodama Masafumi, Ishihara Takeshi, Kuroda Shigetoshi
Abstract excerpt
OBJECTIVE: One of the clinically significant adverse effects of olanzapine treatment is weight gain, which shows substantial inter-individual differences and may be influenced by genetic variation. The aim of this investigation was identification of genetic risk factors associated with olanzapine-induced weight gain. METHOD: Inpatients with DSM-IV-TR schizophrenia (N = 164) were administered olanzapine for 8 to...
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