Article

Correcting Scale Distortion in RNA Sequencing Data

2024-08-22

Abstract excerpt

<title>Abstract</title> <p>RNA sequencing (RNA-seq) is the conventional genome-scale approach used to capture the expression levels of all detectable genes in a biological sample. This is now regularly used in the clinical diagnostic space for cancer patients. While the information gained is intended to impact treatment decisions, numerous technical and quality issues remain. This includes inaccuracies in the dis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d278334-f5f3-55ac-9375-2cb8dec2128d
DOI: 10.21203/rs.3.rs-4745774/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Correcting Scale Distortion in RNA Sequencing DataDOI 10.21203/rs.3.rs-4745774/v1Read

A Simple Bias Reduction Algorithm for RNA Sequencing DatasetsSemantic proximity Read

Enabling cross-study analysis of RNA-Sequencing dataSemantic proximity Read

Technical and Biological Biases in Bulk Transcriptomic Data Mining for Cancer ResearchSemantic proximity Read

Cross-assay RNA modeling reveals cancer biomarkersSemantic proximity Read

Optimizing bioinformatic workflows to extract clinically usable gene expression data from targeted RNA sequencing panels: comparison with total RNAseqSemantic proximity Read

Caris-ComBat-seq: Directionally Harmonizing Large-Scale RNA-seq DatasetsSemantic proximity Read

Robust normalization and transformation techniques for constructing gene coexpression networks from RNA-seq dataSemantic proximity Read

Toward Best Practice in Identifying Subtle Differential Expression with RNA-seq: A Real-World Multi-Center Benchmarking Study Using Quartet and MAQC Reference MaterialsSemantic proximity Read

Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis resultsSemantic proximity Read

Critical Differential Expression Assessment for Individual Bulk RNA-Seq ProjectsSemantic proximity Read

Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA–sequencing dataSemantic proximity Read

A systematic comparison of normalization methods for eQTL analysis.Semantic proximity Read