Article
Collagen type II and a thermo-responsive polymer of N-isopropylacrylamide induce arthritis independent of Toll-like receptors: a strong influence by major histocompatibility complex class II and Ncf1 genes.
The American journal of pathology - 1 Nov 2011
Shakya Akhilesh Kumar, Kumar Ashok, Klaczkowska Dorota, Hultqvist Malin, Hagenow Kristin, Holmdahl Rikard, Nandakumar Kutty Selva
Abstract excerpt
We established and characterized an arthritis mouse model using collagen type II (CII) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNiPAAm). The new PNiPAAm adjuvant is TLR-independent, as all immunized TLR including MyD88-deficient mice developed an anti-CII response. Unlike other adjuvants, PNiPPAm did not skew the cytokine response (IL-1β, IFN-γ, IL-4, and IL-17), as there was no immune...
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