Article
Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients.
Biochemical and biophysical research communications - 31 Dec 1991
Sesti G, Marini M A, Tullio A N, Montemurro A, Borboni P, Fusco A, Accili D, Lauro R
Abstract excerpt
The human insulin receptor gene is expressed in two variant isoforms which differ by the absence (HIR-A) or presence (HIR-B) of 12 amino acids in the COOH-terminus of the extracellular alpha-subunit as a consequence of alternative splicing of exon 11. Expression of the two variant isoforms is reg...
Topics
- 3T3 Cells
- Adipose Tissue
- Amino Acid Sequence
- Animals
- Diabetes Mellitus, Type 2
- Female
- Gene Expression
- Genetic Variation
- Humans
- Immunoglobulin G
- Insulin
- Kinetics
- Macromolecular Substances
- Male
- Mice