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Article

The histone chaperone function of Daxx is dispensable for embryonic development.

Cell death & disease - 26 Aug 2023

Sun Chang, Qi Yuan, Fowlkes Natalie, Lazic Nina, Su Xiaoping, Lozano Guillermina, Wasylishen Amanda R

Abstract excerpt

Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including centromeres, telomeres, and repeat loci. To advance our understanding of histone chaperone activity in vivo, we developed two Daxx mutant alleles in the mouse germline, which...

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Identifiers

PMID: 37633949
DOI: 10.1038/s41419-023-06089-0
PMCID: PMC10460429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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