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Article

Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.

Cell death and differentiation - 1 Oct 2010

Zhang J-H, Panicker L M, Seigneur E M, Lin L, House C D, Morgan W, Chen W C, Mehta H, Haj-Ali M, Yu Z-X, Simonds W F

Abstract excerpt

Parafibromin, a tumor suppressor protein encoded by HRPT2/CDC73 and implicated in parathyroid cancer and the hyperparathyroidism-jaw tumor (HPT-JT) familial cancer syndrome, is part of the PAF1 transcriptional regulatory complex. Parafibromin has been implicated in apoptosis and growth arrest, but the mechanism by which its loss of function promotes neoplasia is poorly understood. In this study we report that a...

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Source

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Identifiers

PMID: 20339377
DOI: 10.1038/cdd.2010.32
PMCID: PMC3109426

Genes

CDC73
PAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.PMID 20339377Read ↗

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