Article
Imprinting defects in mouse embryos: stochastic errors or polymorphic phenotype?
Genesis (New York, N.Y. : 2000) - 1 Sept 2001
Croteau S, Polychronakos C, Naumova A K
Abstract excerpt
Defects in expression of imprinted genes are believed to cause developmental abnormalities and play a role in carcinogenesis. To determine whether spontaneous imprinting defects may occur in mouse embryos, we studied the expression of two imprinted genes H19 and Igf2 in individual postimplantation 7.5 d.p.c. and 8.5 d.p.c. embryos. Biallelic expression of H19 was found in 1.6% of the embryos, whereas biallelic...
Topics
- Alleles
- Animals
- Chromosome Deletion
- Crosses, Genetic
- DNA
- DNA Primers
- Embryo, Mammalian
- Embryonic Development
- Female
- Gene Expression Regulation
- Genomic Imprinting
- Incidence
- Insulin-Like Growth Factor II
- Male
- Methylation
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL