Article
The linker region plays a key role in the adaptation to cold of the cellulase from an Antarctic bacterium.
The Biochemical journal - 15 Oct 2007
Sonan Guillaume K, Receveur-Brechot Véronique, Duez Colette, Aghajari Nushin, Czjzek Mirjam, Haser Richard, Gerday Charles
Abstract excerpt
The psychrophilic cellulase, Cel5G, from the Antarctic bacterium Pseudoalteromonas haloplanktis is composed of a catalytic module (CM) joined to a carbohydrate-binding module (CBM) by an unusually long, extended and flexible linker region (LR) containing three loops closed by three disulfide bridges. To evaluate the possible role of this region in cold adaptation, the LR was sequentially shortened by protein...
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