Article
Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci.
American journal of human genetics - 1 Dec 2006
Bisceglia Luigi, Cerullo Giuseppina, Forabosco Paola, Torres Diletta Domenica, Scolari Francesco, Di Perna Michele, Foramitti Marina, Amoroso Antonio, Bertok Sara, Floege Jürgen, Mertens Peter Rene, Zerres Klaus, Alexopoulos Efstathios, Kirmizis Dimitrios, Ermelinda Mazzucco, Zelante Leopoldo, Schena Francesco Paolo
Abstract excerpt
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, but its etiologic mechanisms are still poorly understood. Different prevalences among ethnic groups and familial aggregation, together with an increased familial risk, suggest important genetic influences on its pathogenesis. A locus for familial IgAN, called "IGAN1," on chromosome 6q22-23 has been described, without the identification of any...
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