Article
Presynaptic ryanodine receptor-activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Jul 2007
Shakiryanova Dinara, Klose Markus K, Zhou Yi, Gu Tingting, Deitcher David L, Atwood Harold L, Hewes Randall S, Levitan Edwin S
Abstract excerpt
Although it has been postulated that vesicle mobility is increased to enhance release of transmitters and neuropeptides, the mechanism responsible for increasing vesicle motion in nerve terminals and the effect of perturbing this mobilization on synaptic plasticity are unknown. Here, green fluorescent protein-tagged dense-core vesicles (DCVs) are imaged in Drosophila motor neuron terminals, where DCV mobility is...
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