Article
Characterization of R peptide of murine leukemia virus envelope glycoproteins in syncytium formation and entry.
Archives of virology - 1 Jan 2007
Kubo Y, Tominaga C, Yoshii H, Kamiyama H, Mitani C, Amanuma H, Yamamoto N
Abstract excerpt
The C-terminal R peptide of ecotropic murine leukemia virus (MLV) envelope protein (Env) negatively controls membrane fusion activity. The R peptide cleavage during virion maturation activates its fusogenicity and is required for viral entry. We analyzed fusogenicity and transduction efficiency of mutant Env proteins of ecotropic, amphotropic, polytropic, and xenotropic MLVs. As the result, we found that the...
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