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Article

Incorporation of genetic model parameters for cost-effective designs of genetic association studies using DNA pooling.

BMC genomics - 16 Jul 2007

Ji Fei, Finch Stephen J, Haynes Chad, Mendell Nancy R, Gordon Derek

Abstract excerpt

BACKGROUND: Studies of association methods using DNA pooling of single nucleotide polymorphisms (SNPs) have focused primarily on the effects of "machine-error", number of replicates, and the size of the pool. We use the non-centrality parameter (NCP) for the analysis of variance test to compute the approximate power for genetic association tests with DNA pooling data on cases and controls. We incorporate genetic...

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Identifiers

PMID: 17634103
DOI: 10.1186/1471-2164-8-238
PMCID: PMC1947971

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Source receipt: pubmed, retrieved 7 Sept 2026.

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