Article
The ABCG8 polymorphism increases the risk of gallbladder cancer in the general population and gallstones in obese patients from Poland.
European journal of clinical investigation - 1 Aug 2024
Krupa Lukasz, Kalinowski Piotr, Ligocka Joanna, Dauer Marc, Jankowski Krzysztof, Gozdowska Jolanta, Kruk Beata, Milkiewicz Piotr, Zieniewicz Krzysztof, Krawczyk Marek, Weber Susanne N, Lammert Frank, Krawczyk Marcin
Abstract excerpt
BACKGROUND: Gallstone disease (GD) is common but remains asymptomatic in most cases. However, gallstones can lead to complications like choledocholithiasis or gallbladder cancer. In this study, we analyse the common genetic risk factor for GD, the p.D19H variant in the sterol transporter ABCG8, in Polish patients with gallstones and gallbladder cancer. METHODS: Three adult cohorts were prospectively recruited: 65...
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