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Article

Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol.

Hepatology (Baltimore, Md.) - 1 Sept 2007

Grünhage Frank, Acalovschi Monica, Tirziu Simona, Walier Maja, Wienker Thomas F, Ciocan Anca, Mosteanu Ofelia, Sauerbruch Tilman, Lammert Frank

Abstract excerpt

UNLABELLED: Genomewide scans of inbred strains of mice have linked the genes encoding the hepatocanalicular cholesterol transporter ABCG5/G8 to gallstone formation. Five nonsynonymous coding single-nucleotide polymorphisms (SNPs) in the orthologous human genes are associated with differences in serum cholesterol and plant sterol levels. We now tested these ABCG5/G8 SNPs for linkage and association with gallstone...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 5
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Source

Identifiers

PMID: 17626266
DOI: 10.1002/hep.21847

Genes

ABCG5
ABCG8
NPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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