Article
Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants.
Biochemical and biophysical research communications - 7 Sept 2007
Dobbyn Helen C, McEwan Paul A, Krause Andre, Novak-Frazer Lily, Bella Jordi, O'Keefe Raymond T
Abstract excerpt
Snu13p is a Saccharomyces cerevisiae protein essential for pre-messenger RNA splicing and pre-ribosomal RNA processing. Snu13p binds U4 snRNA of the spliceosome and box C/D snoRNAs of the pre-ribosomal RNA processing machinery to induce assembly of each ribonucleoprotein complex. Here, we present structural and biochemical analysis of Snu13p. The crystal structure of Snu13p reveals a region of the protein which...
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