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Article

The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome.

EMBO reports - 1 Sept 2002

Bartels Cornelia, Klatt Christine, Lührmann Reinhard, Fabrizio Patrizia

Abstract excerpt

Snu114p is a yeast U5 snRNP protein homologous to the ribosomal elongation factor EF-2. Snu114p exhibits the same domain structure as EF-2, including the G-domain, but with an additional N-terminal domain. To test whether Snu114p in the spliceosome is involved in rearranging RNA secondary structures (by analogy to EF-2 in the ribosome), we created conditionally lethal mutants. Deletion of this N-terminal domain...

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Identifiers

PMID: 12189173
DOI: 10.1093/embo-reports/kvf172
PMCID: PMC1084225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome.PMID 12189173Read ↗

Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing.Semantic proximity Read ↗

Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.Semantic proximity Read ↗

Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation.Semantic proximity Read ↗

An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.Semantic proximity Read ↗

Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.Semantic proximity Read ↗

Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants.Semantic proximity Read ↗

Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome.Semantic proximity Read ↗

The U5 snRNA internal loop 1 is a platform for Brr2, Snu114 and Prp8 protein binding during U5 snRNP assembly.Semantic proximity Read ↗

Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs.Semantic proximity Read ↗

The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.Semantic proximity Read ↗

Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome.Semantic proximity Read ↗

The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.Semantic proximity Read ↗

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