Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP.

doi:10.1261/rna.056911.116

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP.

RNA (New York, N.Y.) - 1 Sept 2016

Agarwal Radhika, Schwer Beate, Shuman Stewart

Abstract excerpt

Luc7 is an essential 261-amino acid protein subunit of the Saccharomyces cerevisiae U1 snRNP. To establish structure-function relations for yeast Luc7, we conducted an in vivo mutational analysis entailing N- and C-terminal truncations and alanine scanning of phylogenetically conserved amino acids, including two putative zinc finger motifs, ZnF1 and ZnF2, and charged amino acids within the ZnF2 module. We...

Topics

Mutation
Nuclear Proteins
RNA Splicing
RNA-Binding Proteins
Ribonucleoprotein, U1 Small Nuclear
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Spliceosomes
Splicing Factor U2AF
Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 27354704
DOI: 10.1261/rna.056911.116
PMCID: PMC4986886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics