Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28.

Nucleic acids research - 1 Apr 2014

Schwer Beate, Shuman Stewart

Abstract excerpt

Yhc1 and U1C are homologous essential subunits of the yeast and human U1 snRNP, respectively, that are implicated in the establishment and stability of the complex of U1 bound to the pre-mRNA 5' splice site (5'SS). Here, we conducted a mutational analysis of Yhc1, guided by the U1C NMR structure and low-resolution crystal structure of human U1 snRNP. The N-terminal 170-amino acid segment of the 231-amino acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoprotein, U1 Small Nuclear

Share to Ribonucleoproteins

Share to Ribonucleoproteins, Small Nuclear

Share to RNA, Small Nuclear

Share to Splicing Factor U2AF

Source

Open in PubMed Open full text

Identifiers

PMID: 24497193
DOI: 10.1093/nar/gku097
PMCID: PMC3985668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28.PMID 24497193Read ↗

Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP.Semantic proximity Read ↗

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeastSemantic proximity Read ↗

Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors.Semantic proximity Read ↗

A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.Semantic proximity Read ↗

U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP BiogenesisSemantic proximity Read ↗

Human snRNP polypeptide D1 promotes pre-mRNA splicing in yeast and defines nonessential yeast Smd1p sequences.Semantic proximity Read ↗

Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor.Semantic proximity Read ↗

Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA.Semantic proximity Read ↗

Functional Analysis of the Zinc Finger Modules of the <i>S. cerevisiae</i> Splicing Factor Luc7Semantic proximity Read ↗

Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation.Semantic proximity Read ↗

Analysis of Snu13p mutations reveals differential interactions with the U4 snRNA and U3 snoRNA.Semantic proximity Read ↗

A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.