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Article

Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene.

The EMBO journal - 2 Jun 2010

Campion Yannick, Neel Henry, Gostan Thierry, Soret Johann, Bordonné Rémy

Abstract excerpt

Spinal muscular atrophy results from deletions or mutations in the survival of motor neuron (SMN1) gene. The SMN protein has an essential role in the biogenesis of spliceosomal snRNPs, but the link between a defect in this process and specific splicing inhibition of pre-mRNAs has not been established. In this study, we report the construction of a temperature-degron (td) allele of the Schizosaccharomyces pombe...

Topics

Alleles
Cell Nucleus
Genes, Fungal
Humans
Introns
Motor Neurons
Muscular Atrophy, Spinal
Mutation
RNA Precursors
RNA Splicing
Ribonucleoproteins
Ribonucleoproteins, Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizosaccharomyces

Schizosaccharomyces pombe Proteins

Spliceosomes

Survival of Motor Neuron 1 Protein

snRNP Core Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20400941
DOI: 10.1038/emboj.2010.70
PMCID: PMC2885929

Genes

SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene.PMID 20400941Read ↗

Characterization of the Schizosaccharomyces pombe orthologue of the human survival motor neuron (SMN) protein.Semantic proximity Read ↗

A mutation in a single gene of Schizosaccharomyces pombe affects the expression of several snRNAs and causes defects in RNA processing.Semantic proximity Read ↗

Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genesSemantic proximity Read ↗

Transcriptomic comparison of <i>Drosophila</i> snRNP biogenesis mutants: implications for Spinal Muscular AtrophySemantic proximity Read ↗

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Semantic proximity Read ↗

Transcriptomic comparison of <i>Drosophila</i> snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophySemantic proximity Read ↗

U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP BiogenesisSemantic proximity Read ↗

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Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular DysfunctionSemantic proximity Read ↗

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron proteinSemantic proximity Read ↗

A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA SplicingSemantic proximity Read ↗

Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism?Semantic proximity Read ↗

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