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Article

Universal distribution of protein evolution rates as a consequence of protein folding physics.

Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 2010

Lobkovsky Alexander E, Wolf Yuri I, Koonin Eugene V

Abstract excerpt

The hypothesis that folding robustness is the primary determinant of the evolution rate of proteins is explored using a coarse-grained off-lattice model. The simplicity of the model allows rapid computation of the folding probability of a sequence to any folded conformation. For each robust folde...

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Identifiers

PMID: 20133769
DOI: 10.1073/pnas.0910445107
PMCID: PMC2840281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20133769-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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