Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intracellular replication is essential for the virulence of Salmonella typhimurium.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991

Leung K Y, Finlay B B

Abstract excerpt

Salmonella typhimurium is a facultative intracellular parasite, capable of penetrating, surviving, and multiplying within diverse eukaryotic cell types, including epithelial and phagocytic cells. We have been studying intracellular replication of S. typhimurium and found that it is essential in the pathogenesis of this bacterium. A total of 45,000 independent mini-Mu MudJ transposon mutants in S. typhimurium...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to HeLa Cells
Share to Kinetics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Mutagenesis, Insertional

Share to Phenotype

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 1763061
DOI: 10.1073/pnas.88.24.11470
PMCID: PMC53157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intracellular replication is essential for the virulence of Salmonella typhimurium.PMID 1763061Read ↗

Molecular characterization of the prototrophic Salmonella mutants defective for intraepithelial replication.Semantic proximity Read ↗

Genetic Determinants of Salmonella enterica Serovar Typhimurium Proliferation in the Cytosol of Epithelial Cells.Semantic proximity Read ↗

Novel Salmonella enterica serovar Typhimurium protein that is indispensable for virulence and intracellular replication.Semantic proximity Read ↗

Characterization of a Salmonella choleraesuis mutant that cannot multiply within epithelial cells.Semantic proximity Read ↗

Intracellular Survival and Pathogenicity Modulation of Salmonella Lon, CpxR, and RfaL Mutants Used as Live Bacterial Vectors under Abiotic Stress, Unveiling the Link between Stress Response and Virulence in Epithelial Cells.Semantic proximity Read ↗

Resistance to host antimicrobial peptides is necessary for Salmonella virulence.Semantic proximity Read ↗

The interplay between Salmonella typhimurium and its macrophage host--what can it teach us about innate immunity?Semantic proximity Read ↗

Identification of genes that are dispensable for animal infection by Salmonella typhimurium.Semantic proximity Read ↗

Salmonella typhimurium thyA mutants fail to grow intracellularly in vitro and are attenuated in mice.Semantic proximity Read ↗

An incomplete TCA cycle increases survival of Salmonella Typhimurium during infection of resting and activated murine macrophages.Semantic proximity Read ↗

At least four percent of the Salmonella typhimurium genome is required for fatal infection of mice.Semantic proximity Read ↗

DNA adenine methylase mutants of Salmonella typhimurium show defects in protein secretion, cell invasion, and M cell cytotoxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.