Article
Characterization of a Salmonella choleraesuis mutant that cannot multiply within epithelial cells.
Canadian journal of microbiology - 1 Jul 1991
Finlay B B, Chatfield S, Leung K Y, Dougan G, Falkow S
Abstract excerpt
A mutant of Salmonella choleraesuis was identified that could invade (enter) and penetrate through polarized monolayers of Caco-2 and MDCK epithelial cells at normal levels but was defective for intracellular multiplication within these cells. It was also able to survive inside cultured J774 macrophage cells. These bacteria remained inside membrane-bound vacuoles, which coalesced at later times in the perinuclear...
Topics
- Animals
- Cell Line
- Epithelium
- Humans
- Kinetics
- Mutation
- Salmonella
- Tumor Cells, Cultured
- Virulence