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Article

An incomplete TCA cycle increases survival of Salmonella Typhimurium during infection of resting and activated murine macrophages.

PloS one - 8 Nov 2010

Bowden Steven D, Ramachandran Vinoy K, Knudsen Gitte M, Hinton Jay C D, Thompson Arthur

Abstract excerpt

BACKGROUND: In comparison to the comprehensive analyses performed on virulence gene expression, regulation and action, the intracellular metabolism of Salmonella during infection is a relatively under-studied area. We investigated the role of the tricarboxylic acid (TCA) cycle in the intracellular replication of Salmonella Typhimurium in resting and activated macrophages, epithelial cells, and during infection of...

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Identifiers

PMID: 21079785
DOI: 10.1371/journal.pone.0013871
PMCID: PMC2975626

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