Article
Molecular characterization of the prototrophic Salmonella mutants defective for intraepithelial replication.
Infection and immunity - 1 Apr 2003
Suvarnapunya Akamol E, Zurawski Daniel V, Guy Rebecca L, Stein Murry A
Abstract excerpt
Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmonella pathogenicity island 2 function underlies the intracellular replication defect of 3-11 and...
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