Resistance to host antimicrobial peptides is necessary for Salmonella virulence.

doi:10.1073/pnas.89.24.11939

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Article

Resistance to host antimicrobial peptides is necessary for Salmonella virulence.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1992

Groisman E A, Parra-Lopez C, Salcedo M, Lipps C J, Heffron F

Abstract excerpt

The production of antibacterial peptides is a host defense strategy used by various species, including mammals, amphibians, and insects. Successful pathogens, such as the facultative intracellular bacterium Salmonella typhimurium, have evolved resistance mechanisms to this ubiquitous type of host defense. To identify the genes required for resistance to host peptides, we isolated a library of 20,000 MudJ...

Topics

Animals
Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Biological Evolution
Blood Proteins
Chromosome Mapping
Cytoplasmic Granules
Defensins
Genes, Bacterial
Genotype
Granulocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

In Vitro Techniques

Magainins

Mice

Mutagenesis

Peptides

Protamines

Source

Open in PubMed Open full text

Identifiers

PMID: 1465423
DOI: 10.1073/pnas.89.24.11939
PMCID: PMC50673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1465423-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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