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Article

Resistance to host antimicrobial peptides is necessary for Salmonella virulence.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1992

Groisman E A, Parra-Lopez C, Salcedo M, Lipps C J, Heffron F

Abstract excerpt

The production of antibacterial peptides is a host defense strategy used by various species, including mammals, amphibians, and insects. Successful pathogens, such as the facultative intracellular bacterium Salmonella typhimurium, have evolved resistance mechanisms to this ubiquitous type of host defense. To identify the genes required for resistance to host peptides, we isolated a library of 20,000 MudJ...

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Identifiers

PMID: 1465423
DOI: 10.1073/pnas.89.24.11939
PMCID: PMC50673

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