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Salmonella typhimurium thyA mutants fail to grow intracellularly in vitro and are attenuated in mice.

Microbiology (Reading, England) - 1 Mar 2001

Kok Menno, Bühlmann Elisabeth, Pechère Jean-Claude

Abstract excerpt

Salmonella typhimurium ATCC14028 readily multiplies in professional phagocytes in vitro and is highly virulent in mice. Mutants lacking thymidylate synthase activity (thyA) were isolated and shown to be strictly dependent on thymidine monophosphate precursors in the growth medium. The thyA mutants were found to be virtually incapable of intracellular growth and survival in vitro, both in macrophage-like cell line...

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Identifiers

PMID: 11238980
DOI: 10.1099/00221287-147-3-727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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