Article
Association between BanI genotype and increased phospholipase A2 activity in schizophrenia.
European archives of psychiatry and clinical neuroscience - 1 Sept 2007
Barbosa Nadia R, Junqueira Ricardo M, Vallada Homero P, Gattaz Wagner F
Abstract excerpt
Phospholipases A2 (PLA2) are a family of key enzymes in the metabolism of membrane phospholipids. Several studies reported on increased blood and brain PLA2 activity in schizophrenia, which suggest a disordered phospholipid metabolism in the disease. In addition, a genetic variant of a cytosolic PLA2 gene has been reported to be associated with schizophrenia. These data indicate that variants of PLA2 encoding...
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