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Article

Targeting two-component signal transduction: a novel drug discovery system.

Methods in enzymology - 1 Jan 2007

Okada Ario, Gotoh Yasuhiro, Watanabe Takafumi, Furuta Eiji, Yamamoto Kaneyoshi, Utsumi Ryutaro

Abstract excerpt

We have developed two screening systems for isolating inhibitors that target bacterial two-component signal transduction: (1) a differential growth assay using a temperature-sensitive yycF mutant (CNM2000) of Bacillus subtilis, which is supersensitive to histidine kinase inhibitors, and (2) a hig...

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PMID: 17628150
DOI: 10.1016/S0076-6879(06)22019-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17628150-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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