Article
Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules.
Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2010
Ng Wai-Leung, Wei Yunzhou, Perez Lark J, Cong Jianping, Long Tao, Koch Matthew, Semmelhack Martin F, Wingreen Ned S, Bassler Bonnie L
Abstract excerpt
Bacterial histidine kinases transduce extracellular signals into the cytoplasm. Most stimuli are chemically undefined; therefore, despite intensive study, signal recognition mechanisms remain mysterious. We exploit the fact that quorum-sensing signals are known molecules to identify mutants in the Vibrio cholerae quorum-sensing receptor CqsS that display altered responses to natural and synthetic ligands. Using...
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