Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers.

Dementia and geriatric cognitive disorders - 1 Jan 2007

Lamsa R, Helisalmi S, Herukka S-K, Tapiola T, Pirttila T, Vepsalainen S, Hiltunen M, Soininen H

Abstract excerpt

BACKGROUND: In Alzheimer's disease (AD) the beta-amyloid precursor protein is excessively cleaved into Abeta(42), causing the abundant amyloid plaque loads in affected brain areas. Sterol O-acyltransferase 1 (SOAT1) has been found to regulate the production of beta-amyloid precursor protein. METHODS: We genotyped 4 SOAT1 single nucleotide polymorphism (SNP) sites (rs2247071, rs2862616, rs3753526 and rs1044925) in...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease
Share to Amyloid beta-Peptides
Share to Biomarkers
Share to Haplotypes
Share to Peptide Fragments
Share to Phosphorylation
Share to tau Proteins

Source

Identifiers

PMID: 17622762
DOI: 10.1159/000105164

Genes

SOAT1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers.PMID 17622762Read ↗

Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease.Semantic proximity Read ↗

Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese.Semantic proximity Read ↗

Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).Semantic proximity Read ↗

A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.Semantic proximity Read ↗

OAS1 rs1131454 genetic variant is associated with Alzheimer's disease: an epidemiological analysis.Semantic proximity Read ↗

Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.Semantic proximity Read ↗

Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease.Semantic proximity Read ↗

Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease.Semantic proximity Read ↗

Genetic study evaluating LDLR polymorphisms and Alzheimer's disease.Semantic proximity Read ↗

SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan.Semantic proximity Read ↗

Association analysis of the paraoxonase-1 gene with Alzheimer's disease.Semantic proximity Read ↗

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.