Article
Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease.
Molecular psychiatry - 1 Jun 2003
Wollmer M A, Streffer J R, Tsolaki M, Grimaldi L M E, Lütjohann D, Thal D, von Bergmann K, Nitsch R M, Hock C, Papassotiropoulos A
Abstract excerpt
A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations...
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