SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

doi:10.1093/hmg/ddu372

Article

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

Human molecular genetics - 15 Dec 2014

Ramirez Alfredo, van der Flier Wiesje M, Herold Christine, Ramonet David, Heilmann Stefanie, Lewczuk Piotr, Popp Julius, Lacour André, Drichel Dmitriy, Louwersheimer Eva, Kummer Markus P, Cruchaga Carlos, Hoffmann Per, Teunissen Charlotte, Holstege Henne, Kornhuber Johannes, Peters Oliver, Naj Adam C, Chouraki Vincent, Bellenguez Céline, Gerrish Amy, Heun Reiner, Frölich Lutz, Hüll Michael, Buscemi Lara, Herms Stefan, Kölsch Heike, Scheltens Philip, Breteler Monique M, Rüther Eckart, Wiltfang Jens, Goate Alison, Jessen Frank, Maier Wolfgang, Heneka Michael T, Becker Tim, Nöthen Markus M

Abstract excerpt

Cerebrospinal fluid amyloid-beta 1-42 (Aβ1-42) and phosphorylated Tau at position 181 (pTau181) are biomarkers of Alzheimer's disease (AD). We performed an analysis and meta-analysis of genome-wide association study data on Aβ1-42 and pTau181 in AD dementia patients followed by independent replication. An association was found between Aβ1-42 level and a single-nucleotide polymorphism in SUCLG2 (rs62256378) (P =...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.PMID 25027320Read

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease.Semantic proximity Read

Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers.Semantic proximity Read

<i>PLCG2</i> as a Risk Factor for Alzheimer’s DiseaseSemantic proximity Read

Genetics of Alzheimer's disease: where we are, and where we are going.Semantic proximity Read

PLCG2 as a Risk Factor for Alzheimer's DiseaseSemantic proximity Read

Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unitSemantic proximity Read

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.Semantic proximity Read

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.Semantic proximity Read